MIP6 — Saccharomyces cerevisiae S288c

Summary

YHR015W in Saccharomyces cerevisiae S288c encodes a protein with RNA nuclease inhibitor activity and phase separation nucleator activity. It contains multiple RRM domains characteristic of the Nop13/Rnp24 and Hrp1 families. The protein localizes to the cytoplasm, nucleus, ribosomes, stress granules, and post-mRNA release spliceosomal complexes. It is associated with regulation of translational initiation, mRNA stability, poly(A) tail shortening, and translational readthrough. YHR015W is associated with responses to hypoxia, UV-A, and oxidative stress, as well as with nucleosome disassembly, GMP and acetate anabolism, and PKC signal transduction. Phenotypic associations include decreased anaerobic growth, UV resistance, starvation resistance, and vegetative growth, along with altered metal and chemical resistance, abnormal vacuolar morphology, and increased competitive fitness. The gene is also associated with chromosome division, meiosis, and mitosis.