SLT2 — Saccharomyces cerevisiae S288c

Summary

YHR030C encodes a protein serine kinase with ATP-dependent protein binding activity, belonging to the MAP kinase family (MAPK_p38-like). This gene is associated with a wide range of biological processes, including PKC signal transduction, cell wall assembly and organization, 1,3-beta-glucan and chitin anabolism, mRNA stabilization and breakdown, pinocytosis, cell cycle transition, regulation of autophagy and growth, and responses to ethanol, heat, and ER stress. It localizes to the cytoplasm, nucleus, cytosol, mitotic spindle pole body, and cell division site. The gene is linked to numerous traits and phenotypes, including decreased cell size, abnormal cell wall morphology, reduced biofilm formation, increased desiccation resistance, decreased osmotic stress and alkaline pH resistance, delayed G1 phase progression, and altered RNA accumulation. Studies of related genes in other species link the family to mitogen-activated protein kinase activity (EC 2.7.11.24) and to loss of pathogenicity and reduced virulence.