RRM3 — Saccharomyces cerevisiae S288c

Summary

YHR031C in Saccharomyces cerevisiae S288c encodes a protein with 5'-3' DNA helicase, 5'-3' DNA/RNA helicase, G4 unwinding, DNA reannealing, 3'-5' exonuclease, and ATP-dependent protein-DNA complex displacement activities, along with telomerase inhibitor activity and binding to G-DNA, flap-structured DNA, telomeres, centromeres, and single-stranded DNA. This gene is associated with negative regulation of telomere maintenance via telomerase, upregulation of DNA repair, DNA recombination, gene conversion, mismatch repair, replication fork reversal, bypass DNA synthesis, transposition, spindle assembly, sister chromatid cohesion, and the glyoxylate cycle. It localizes to the nuclear replisome, nuclear replication fork, chromosome telomeric repeat region, chromatin, nucleolus, mitochondria, and site of double-strand breaks. Phenotypic associations include increased telomere length, mitotic recombination, and transposition, along with delayed cell cycle progression, decreased growth, increased heat sensitivity, reduced stress resistance, and abnormal budding and morphology.