TOM71 — Saccharomyces cerevisiae S288c

Summary

YHR117W from Saccharomyces cerevisiae S288c encodes a protein with membrane insertase activity, ATPase inhibitor activity, Hsp90 binding, mitochondrion targeting sequence binding, protein translocase activity, and bridging binding. It is associated with protein import, mitochondrial biogenesis, protein-mitochondrial targeting, antiviral response, posttranslational protein targeting to the ER membrane, TOM complex assembly, mitochondrial inner membrane protein import, amino acid breakdown, mitochondrial unfolded protein response, mitochondrial matrix protein import, cell death, phospholipid homeostasis, mitochondrial fission, mitochondrion distribution, sphingolipid metabolism, ATP anabolism, structural organization, and response to amino acid. The protein localizes to the TRC complex, mitochondrial outer membrane translocase complex, mitochondrial outer membrane, mitochondria, membrane, cytoplasm, cytosol, and nucleus. It is linked to increased nutrient utilization, abnormal mitochondrial genome maintenance, decreased respiratory growth rate, increased replicative lifespan, increased protein/peptide accumulation, abnormal protein/peptide distribution, decreased oxidative stress resistance, decreased toxin resistance, haploinsufficiency, decreased vegetative growth rate, abnormal vacuolar morphology, decreased competitive fitness, viability, and decreased chemical resistance.