SSM4 — Saccharomyces cerevisiae S288c

Summary

YIL030C in Saccharomyces cerevisiae S288c encodes a protein with ubiquitin ligase activity and zinc-binding capacity, placing it in the RING-CH and RING/FYVE/PHD zinc-finger domain families. The gene is associated with numerous cellular processes including protein quality control, the ERAD pathway, lipid A and ergosterol anabolism, adiposome formation, phospholipid homeostasis, glycosylation, proteolysis, meiosis, anaphase, organelle organization, mitochondrial DNA replication, and nitric oxide storage. It localizes to the endoplasmic reticulum membrane and nuclear inner membrane. Phenotypic associations link YIL030C to decreased replicative lifespan, altered vegetative growth rate, increased or decreased chemical resistance, increased competitive fitness, and altered protein and chemical compound accumulation. Studies of related genes in other species further connect the family to ubiquitination activity.