OST1 — Saccharomyces cerevisiae S288c

Summary

YJL002C (OST1) in Saccharomyces cerevisiae encodes a ribophorin I family protein and a subunit of the oligosaccharyltransferase (OST) complex. The gene is associated with protein glycosylation, cotranslational modification, and Golgi vesicle, vacuolar, and protein secretion transport. It has been linked to apoptotic process, mitochondrial genome maintenance, double-strand break repair, protein folding, lipid metabolism, ribosome biogenesis, sporulation, and vacuolar protein sorting. Localised to the ER, nuclear membrane-ER network, and cortical ER, OST1 is associated with oxidative stress, altered growth in exponential phase, increased flocculation and innate thermotolerance, altered toxin and chemical resistance, decreased vegetative growth and competitive fitness, and haploid insufficiency. Related genes in other species support the family’s role in glycosylation and ER function.