BCK1 — Saccharomyces cerevisiae S288c

Summary

YJL095W (BCK1) in Saccharomyces cerevisiae encodes a protein with MEKK activity, protein serine/threonine kinase activity, ATP binding and metal binding, and is annotated with the MAP_kinase_kinase_kinase domain. It is associated with PKC signal transduction, MAPK cascade, cell wall assembly and biogenesis, glucan, mannan and chitin anabolism, cell morphogenesis, regulation of growth, response to heat and nutrient, mitophagy, mRNA transcription, tRNA wobble uridine modification, and electron transport chain. The protein localises to the division septum, cell tip, cell division site, plasmalemma, cytoplasm and cytosol. Phenotypic associations include decreased osmotic stress resistance, decreased acquired thermotolerance, decreased mitophagy and autophagy, decreased cell size, decreased chronological lifespan, increased cold sensitivity, decreased acid and alkaline pH resistance, decreased desiccation resistance, decreased oxidative stress resistance, abnormal vegetative growth, and decreased respiratory growth. Related genes in other species, including MST11 in rice, are linked to loss of pathogenicity.