CDC6 — Saccharomyces cerevisiae S288c

Summary

YJL194W (CDC6) in Saccharomyces cerevisiae S288c encodes a protein with ATP hydrolase activity that binds DNA replication origins and chromatin, and is a member of the Cdc6/18 and AAA+ ATPase families. The gene is associated with cell cycle control, including DNA replication initiation, pre-replicative complex assembly, G1 phase progression, and the spindle checkpoint, as well as meiosis I and II, nuclear division, and wound healing. It localizes to the nucleus, chromatin, the nuclear replication fork, and the origin recognition complex. Phenotypic associations link CDC6 to cell cycle arrest in G1 and metaphase, delayed S phase, increased mutation frequency and mitotic recombination, decreased UV resistance, altered metal and toxin resistance, reduced vegetative growth and competitive fitness, and inviability. Studies of related genes in other yeasts connect the family to MCM complex loading.