SOD1 — Saccharomyces cerevisiae S288c

Summary

YJR104C (SOD1) on chromosome X of Saccharomyces cerevisiae S288c encodes a copper-binding superoxide dismutase with oxidoreductase activity acting on sulphur-group donors with oxygen as acceptor (EC 1.15.1.1). The gene is associated with cellular response to oxidative stress, response to superoxide, and cellular detoxification, as well as with lysine metabolism, sulfide oxidation, lipid and protein oxidation, DNA condensation, and iron transport. It has been linked to traits including oxygen sensitivity, copper concentration and sensitivity, oxidative stress, light sensitivity, and acid sensitivity. Phenotypic associations include decreased viability, decreased exponential-phase growth, increased mutation frequency, decreased replicative lifespan, abnormal redox state, increased prion formation, and altered sporulation efficiency. The product localises to the cytoplasm, nucleus, mitochondria, mitochondrial envelope lumen, and extracellular space.