RAD27 — Saccharomyces cerevisiae S288c

Summary

YKL113C in Saccharomyces cerevisiae S288c encodes a protein with 5'-3' exonuclease and 5' flap endonuclease activities, DNA binding, and magnesium binding. The gene is associated with multiple DNA repair pathways including base excision repair, nucleotide excision repair, mismatch repair, and postreplication repair, as well as telomere maintenance, DNA recombination, gene conversion, and bypass DNA synthesis. It is linked to replicative senescence, cell killing, response to cadmium, and mRNA breakdown. Phenotypic associations include increased mitotic recombination and mutation frequency, decreased replicative and chronological lifespan, reduced UV and oxidative stress resistance, altered cell and bud morphology, and changes in sugar content and salt sensitivity. The protein localises to the nucleus, nucleolus, nucleoplasm, cytoplasm, cytosol, and mitochondria. Related genes in other species link the family to 3.1.-.- exonuclease activity.