RTT109 — Saccharomyces cerevisiae S288c

Summary

YLL002W in Saccharomyces cerevisiae S288c encodes a histone acetyltransferase with H3K56 acetyltransferase activity, placing it in the Rtt109/CBP family of histone-modifying enzymes. The gene is associated with numerous nuclear processes, including nucleosome assembly, chromosome positioning, telomere localization, and DNA damage response pathways such as double-strand break repair and non-homologous end joining. It is linked to cell cycle checkpoint modulation, mRNA metabolism, gene conversion, and transposition. Localization evidence connects the product to the nucleus, chromatin, and vacuole. Phenotypic associations include increased mitotic recombination and transposable element transposition, altered cell cycle progression, decreased fermentative and respiratory growth, reduced thermotolerance and UV resistance, and changes in protein accumulation and stress responses. Studies of related genes in other species link the family to histone acetylation and chromatin regulation.