HSP104 — Saccharomyces cerevisiae S288c

Summary

YLL026W (HSP104) on chromosome XII of Saccharomyces cerevisiae encodes an ATP-dependent protein disaggregase with ATP hydrolase activity that binds misfolded, unfolded and chaperone proteins. It is associated with protein unfolding, denaturation and oligomerization, response to heat and ATP, nuclear envelope budding, viral gene expression, amyloid fibril formation, stress granule disassembly, aggrephagy, ubiquitin recycling, mitochondrial genome maintenance, translation reinitiation, cytokinesis, and nitric oxide storage. The gene is linked to decreased prion inheritance and loss, decreased acquired and innate thermotolerance, increased heat sensitivity, decreased replicative lifespan and vegetative growth rate, altered protein accumulation and distribution, increased telomere length, and altered toxin and chemical resistance. It localizes to the cytoplasm, cytosol, nucleus, nuclear envelope, mitochondrial lumen and protein aggregate center.