COF1 — Saccharomyces cerevisiae S288c

Summary

YLL050C in Saccharomyces cerevisiae S288c encodes a member of the ADF/cofilin family, an actin-binding protein with actin debranching and depolymerizing activities, as well as G-actin and F-actin binding. It is associated with F-actin severing, actin polymerization and depolymerization, cytokinesis, contractile ring assembly, endocytosis, secretion, Golgi-to-plasma membrane transport, cell cycle progression and checkpoint control, cell growth, mitochondrial distribution, and cellular sphingolipid homeostasis. The protein localizes to the actin cytoskeleton, actin patch, medial ring, mitotic actomyosin contractile ring, cell tip, cell division site, nuclear matrix, cytoplasm, and cytosol. Phenotypic associations include abnormal actin cytoskeleton morphology and endocytosis, decreased protein transport and secretion, cell cycle arrest, abnormal mitochondrial morphology, increased heat sensitivity, altered chemical resistance, decreased vegetative growth and competitive fitness, and inviability. Related genes in other species link the family to actin dynamics.