SSK1 — Saccharomyces cerevisiae S288c

Summary

YLR006C (SSK1) on chromosome XII of Saccharomyces cerevisiae S288c encodes a protein with histidine kinase activity, phosphorelay sensor kinase activity, phosphorelay response regulator activity, and protein kinase activator activity, and it binds ATP. SSK1 is associated with mRNA transcription, glycerol anabolism, the ER stress response, osmotic response, mitophagy, cell wall biogenesis, the MAPK cascade, the TCA cycle, protein kinase A signaling, regulation of cellular response to oxidative stress, anaerobic respiration, regulation of filamentous growth, osmolarity sensing, chemotaxis, activation of the p38 cascade, immune evasion, and detoxification. It localizes to the Mcs4 RR-MAPKKK complex, the cell division site, the membrane, and the cytoplasm. The gene is linked to oxidative stress and acid sensitivity, and phenotypes include decreased mitophagy, increased sporulation efficiency, abnormal actin cytoskeleton and cellular morphology, decreased killer toxin resistance, increased cell size, and altered stress, metal, and chemical resistances. Studies of related genes in other species link the family to histidine kinase activity (EC 2.7.13.3) and altered virulence.