GAL2 — Saccharomyces cerevisiae S288c

Summary

YLR081W (GAL2) in Saccharomyces cerevisiae S288c encodes a high-affinity galactose and glucose proton symporter, also annotated with hexose, gluconate and D-glucose transmembrane transporter activity. The protein belongs to the major facilitator superfamily (MFS) of sugar transporters. GAL2 is associated with the Leloir pathway, galactose metabolism, hexose breakdown, and pentose metabolism including arabinose and D-xylose fermentation. It has been linked to glucose detection, maltose and sucrose transport, gluconate import, and cAMP biosynthesis. Localisation evidence places the product at the plasma membrane, cell tip, cell division site, cytoplasm, vacuole and mitochondrial membrane. Phenotypic associations include decreased nutrient uptake, carbon source utilisation, vegetative growth and competitive fitness, increased resistance to chemicals and toxins, abnormal vacuolar morphology, and absence of spore germination. The gene is also associated with oxidative stress. Studies of related genes in other species link the family to hexose transport.