HAP1 — Saccharomyces cerevisiae S288c

Summary

YLR256W, also known as HAP1 in Saccharomyces cerevisiae S288c, encodes a DNA-binding transcription factor with both repressor and RNA polymerase II-specific activator activity, containing a Zn2-C6 fungal-type DNA-binding domain. The protein localizes to the nucleus and mitochondria. It is associated with the regulation of heme, cytochrome, and sterol anabolism, as well as heme a breakdown, cellular respiration, and responses to oxygen levels, hypoxia, and anoxia. The gene has been linked to traits including protein content and oxidative stress. Observed phenotypes include increased exponential growth rate, increased cell size, decreased anaerobic growth, altered mitochondrial morphology and rho- mutation frequency, and changes in RNA, protein, and chemical compound accumulation. Related genes in other species link the family to mitochondrial function.