SIR3 — Saccharomyces cerevisiae S288c

Summary

YLR442C, also known as ORC1 or SIR3 on chromosome XII of Saccharomyces cerevisiae S288c, encodes a protein with DNA replication origin binding, chromatin binding, and ATP hydrolase activities. The gene is associated with telomeric silencing, meiotic telomere clustering, centromere clustering, nucleus organization, sexual reproduction, prophase, transposition, cell wall biogenesis, protein deacetylation, biofilm formation, antigenic variation, oxidative phosphorylation, cell cycle processes, DNA protection, mitochondrial translation, uracil anabolism, and telomere organization. It is linked to traits including phosphate content and oxidative stress, and to phenotypes such as sterility, decreased viability, abnormal meiosis, decreased replicative lifespan, decreased silencing, increased killer toxin resistance, decreased respiratory growth, decreased vegetative growth rate, and abnormal colony and vacuolar morphology. The protein localizes to the nuclear ORC.