YAP1 — Saccharomyces cerevisiae S288c

Summary

YML007W, also known as PAR1 in Saccharomyces cerevisiae S288c, encodes a DNA-binding transcription activator with RNA polymerase II-specific activity, belonging to the bZIP YAP transcription factor family. The protein localises to the nucleus, chromatin, and transcription regulator complexes. This gene is associated with responses to oxidative stress, cadmium, mercury, and osmotic stress, as well as programmed cell death, cellular detoxification, glutathione metabolism, and ethanol anabolism. It is linked to traits including oxidative stress, light sensitivity, and calcium sensitivity. Phenotypic associations include decreased replicative and chronological lifespan, decreased viability, increased mutation frequency and transposable element transposition, abnormal cell cycle progression, and altered metal, toxin, and stress resistance. Studies of related genes in other species link the family to virulence.