ORC1 — Saccharomyces cerevisiae S288c

Summary

YML065W (ORC1) in Saccharomyces cerevisiae S288c encodes a protein with DNA replication origin binding, chromatin binding, ATP hydrolase activity, metal binding, and ATP binding, and contains ORC1/CDC6, BAH, and AAA+ ATPase domains. YML065W is associated with cell cycle processes including pre-replicative complex assembly, MCM complex loading, G1/S phase transition, S phase progression, and spindle assembly checkpoint. It is linked to chromatin organization, nucleosome organization, telomeric silencing, sister chromatid cohesion, and positive regulation of DNA replication initiation. Localized to the nucleus, nuclear ORC, and pre-replicative complex, the gene is associated with viability, vegetative growth rate, heat sensitivity, killer toxin resistance, and chromosome maintenance. Studies of related genes in other species link the family to cell cycle control and DNA replication.