CDC5 — Saccharomyces cerevisiae S288c

Summary

YMR001C in Saccharomyces cerevisiae S288c encodes a protein with histone H3S10 kinase activity, protein serine/threonine kinase activity, and ATP binding, containing POLO box and protein kinase domains. This gene is associated with meiotic chromosome condensation, rDNA packaging, spindle pole body separation, asymmetric cell division, regulation of exit from meiosis, somatic embryogenesis, chromosome condensation, EMTOC assembly, nuclear movement, DNA metabolism, mitotic recombination, mitotic cell cycle, mitotic exit, stem cell renewal, and TOR signaling. It localizes to kinetochore microtubules, the meiotic spindle midzone, inner kinetochore, spindle, spindle midzone, and the CPC complex. YMR001C is associated with cell cycle arrest in anaphase, abnormal chromosome segregation, defective meiosis, absent sporulation, increased cell size, decreased UV resistance, and altered oxidative stress response. Studies of related genes in other species connect the family to cell cycle regulation.