SEC14 — Saccharomyces cerevisiae S288c

Summary

YMR079W (SEC14) in Saccharomyces cerevisiae S288c encodes a protein with phosphatidylcholine carrier activity, phosphatidylinositol carrier activity, and phosphoinositide binding. The protein belongs to the CRAL-TRIO domain family and localizes to the Golgi membrane, plasma membrane, cell tip, and cytosol. YMR079W is associated with intracellular lipid transport, phospholipid metabolism, TOR signaling, secretion, membrane assembly, and regulation of receptor-mediated endocytosis. It has been linked to spore formation, autophagy, and meiosis, as well as to traits including oxidative stress, heat sensitivity, toxin resistance, and vegetative growth. Phenotypic associations include decreased protein secretion, abnormal endomembrane system morphology, and increased chemical compound accumulation. Related genes in other species link these proteins to root hair tip growth.