SPC24 — Saccharomyces cerevisiae S288c

Summary

YMR117C (SPC24) in Saccharomyces cerevisiae S288c encodes a component of the Ndc80 complex, a microtubule-binding protein associated with kinetochore assembly and spindle checkpoint function. The gene product localises to the nucleus and is associated with chromosome biorientation, spindle elongation, centromere clustering, and metaphase progression. It is associated with cell division, DNA replication, asymmetric cell division, and response to glucose, as well as protein kinase A signaling and cellular sphingolipid homeostasis. Phenotypic associations include abnormal chromosome segregation, increased colony sectoring, decreased innate thermotolerance and starvation resistance, heat sensitivity, reduced competitive fitness, and altered chemical resistance.