ADH2 — Saccharomyces cerevisiae S288c

Summary

YMR303C (ADH2) on chromosome XIII of Saccharomyces cerevisiae S288c encodes a protein with aldo-keto reductase (NAD) activity and zinc binding, and belongs to the ADH zinc-binding and NAD(P)-binding domain superfamilies. The gene is associated with numerous anabolic and catabolic processes, including lutein, sterol, carotene, 1-butanol, isobutanol, valine, and amino acid anabolism, as well as methanal metabolism, glycerol breakdown, the shikimate pathway, acetyl-CoA metabolism, and the carnitine shuttle. It is also linked to glycosylation, protein palmitoylation, response to zinc, and clotting. Localization evidence places the product in the cytoplasm, mitochondrial lumen, and fungal biofilm matrix. Trait associations include glucose content, biomass yield, and oxidative stress. Phenotypic connections include increased filamentous growth and chronological lifespan, altered chemical compound accumulation, abnormal vacuolar morphology, and altered resistance to chemicals. Studies of related genes in other species link the family to alcohol dehydrogenase (EC 1.1.1.1) activity.