SSN8 — Saccharomyces cerevisiae S288c

Summary

YNL025C (SSN8) on chromosome XIV of Saccharomyces cerevisiae encodes a cyclin/Ssn8 family protein with cyclin-dependent protein serine/threonine kinase regulator activity and RNA polymerase II core promoter sequence-specific DNA binding. It is a component of the Mediator complex and localises to the nucleus. SSN8 is associated with diverse biological processes including pseudohyphal and filamentous growth, invasive growth, the glucose effect, response to hypoxia, signal transduction, DNA repair, regulation of autophagy, metal ion and polyamine transport, and response to ethanol. The gene is linked to numerous phenotypes such as altered vegetative growth rate, decreased sporulation, increased telomere length, decreased chronological lifespan, altered stress resistance including oxidative stress and heat sensitivity, and changes in nutrient utilisation, metal resistance, and toxin resistance.