APC1 — Saccharomyces cerevisiae S288c

Summary

YNL172W encodes a protein that is annotated with proteasome binding and bridging functions and localizes to the cyclosome, nucleus, and cytosol. It is associated with mitotic cell cycle regulation, including the metaphase/anaphase transition, sister chromatid separation, spindle checkpoint, and telophase. The gene is linked to protein K11-linked ubiquitination, proteasome degradation, and the APC-dependent catabolic process. It also connects to DNA replication checkpoint, chromatin silencing, and protein localization to organelles. Phenotypic associations include haploinsufficiency and inviability, as well as altered competitive fitness and chemical resistance. Studies of related genes in other species link the APC1 family to cell cycle progression and checkpoint control.