NRD1 — Saccharomyces cerevisiae S288c

Summary

YNL251C (NRD1) in Saccharomyces cerevisiae S288c on chromosome XIV encodes a nuclear RNA-binding protein that contains an Nrd1/Seb1 RRM domain, a CID domain, and an ENTH/VHS domain. The protein binds RNA polymerase II C-terminal domain, long non-coding RNA, snoRNA, and RNA, and acts as a chromatin adaptor and phase separation nucleator. NRD1 is associated with RNA surveillance, nuclear mRNA breakdown, snoRNA and regulatory ncRNA 3'-end processing, transcriptional attenuation, and cellular responses to nutrients and glucose. It localizes to the nucleus and Mei2 dots. The gene is linked to abnormal RNA accumulation, increased cell size, increased invasive growth, decreased vegetative and exponential-phase growth, increased heat sensitivity, altered mitochondrial genome maintenance, and altered chemical resistance. Related genes in other species are linked to RNA 3' end processing.