LYP1 — Saccharomyces cerevisiae S288c

Summary

YNL268W in Saccharomyces cerevisiae S288c encodes a basic amino acid permease, a transmembrane transporter with activity for L-histidine, L-arginine, L-lysine, and other amino acids, belonging to the fungal amino acid permease family. This gene is associated with the transport of basic amino acids, lysine, and L-arginine across membranes, as well as with the regulation of proline and arginine metabolism, urea breakdown, fatty acid transport, exocyst assembly, plasmid recombination, and the DNA damage response. It is linked to the eisosome, fungal-type cell wall, and plasma membrane. Phenotypic associations include increased replicative lifespan, decreased heat sensitivity, decreased starvation and oxidative stress resistance, abnormal vacuolar morphology, altered chemical compound accumulation, and decreased vegetative growth rate. Studies of related genes in other species connect the family to general amino acid transport.