SIN3 — Saccharomyces cerevisiae S288c

Summary

YOL004W (SIN3) on chromosome XV of Saccharomyces cerevisiae S288c encodes a transcription corepressor with bridging binding activity, a member of the Sin3-like protein family. Sin3 is associated with negative regulation of transcription by RNA polymerase II, regulation of gene expression, and response to starvation and inositol. It has been connected to replicative senescence, mitophagy, mitochondrial gene expression, pseudohyphal growth, DNA damage checkpoint, centromeric sister chromatid cohesion, and nuclear division. The protein localises to chromatin, the nucleus, cytosol, and the Clr6-LE complex. Sin3 is linked to numerous phenotypes including decreased chronological lifespan, increased cell size, decreased sporulation, altered telomere length, and sensitivity to UV light, oxidative stress, and light. It is also associated with decreased respiratory growth, increased transposable element transposition, and abnormal colony appearance.