HTZ1 — Saccharomyces cerevisiae S288c

Summary

YOL012C in Saccharomyces cerevisiae S288c encodes a histone H2A family protein, a structural constituent of chromatin with chromatin DNA binding, protein heterodimerization activity, and RNA polymerase II cis-regulatory region sequence-specific DNA binding. It localizes to the nucleosome, euchromatin, and nucleus. The gene is associated with numerous biological processes including tyrosine anabolism, non-stop decay, metaphase, CENP-A eviction from euchromatin, nucleotide excision repair, telomere maintenance, sister chromatid cohesion, cell wall organization, response to oleate, DNA damage response, methylation, peptide transport, rDNA packaging, homologous recombination, chromosome division, S phase, ribosome biogenesis, and sporulation. It is linked to traits such as potassium concentration, calcium sensitivity, acid sensitivity, and oxidative stress. Phenotypic associations include abnormal budding index, cell cycle progression, nuclear morphology, and cellular morphology, as well as increased sporulation efficiency and filamentous growth, decreased alkaline pH resistance, UV resistance, and stress resistance, and altered chronological lifespan.