RRP6 — Saccharomyces cerevisiae S288c

Summary

YOR001W (RRP6) on chromosome XV of Saccharomyces cerevisiae S288c encodes a 3'-5' exoribonuclease with RNA exonuclease activity, single-stranded RNA binding, nucleotide binding, and metal binding. It is a core component of the nuclear exosome (RNase complex) and localizes to the nucleolus, nucleoplasm, chromatin, cleavage bodies, and Mmi1 nuclear foci. RRP6 is associated with RNA surveillance, RNA stabilization, RNA 3' end processing, rRNA and mRNA breakdown, histone mRNA catabolism, nuclear polyadenylation-dependent snRNA and snoRNA catabolic processes, telomere maintenance, DNA metabolism, mannosylation, and protein glycosylation. The gene is linked to phenotypes including altered RNA accumulation and localization, decreased replicative lifespan and vegetative growth, increased filamentous growth, altered stress resistance (including heat, cold, UV, and oxidative stress), and increased resistance to toxins and chemicals.