RAT1 — Saccharomyces cerevisiae S288c

Summary

YOR048C, also known as RAT1 on chromosome XV of Saccharomyces cerevisiae S288c, encodes a protein with 5'-3' RNA exonuclease activity, as well as recombinase activity, microtubule binding, rRNA binding, RNA binding, and zinc binding. This gene is associated with RNA surveillance, RNA breakdown, RNA localization, telomeric silencing, mRNA transcription by RNA polymerase II, negative regulation of transcription elongation, NAD-cap decapping, termination of RNA polymerase II transcription, cleavage of the tricistronic rRNA transcript, nuclear export, sno(s)RNA processing, and upregulation of chromosome segregation and RNA 3'-end formation. It is linked to the TXT complex, Las1 complex, and nucleus. Phenotypes associated with RAT1 include increased RNA modification, delayed S phase progression, abnormal RNA localization and accumulation, decreased telomere length, decreased nucleolus size, decreased silencing, increased invasive growth, decreased chromosome maintenance, inviability, decreased vegetative growth, increased heat sensitivity, haploinsufficiency, decreased competitive fitness, and decreased chemical resistance. Studies of related genes in other species link the family to reduced virulence.