MKK1 — Saccharomyces cerevisiae S288c

Summary

YOR231W in Saccharomyces cerevisiae S288c encodes a protein with MAPKK activity, protein tyrosine kinase activity, and protein serine/threonine kinase activity, and it belongs to the protein kinase domain family. The gene is associated with the pheromone response MAPK cascade, signal transduction, protein phosphorylation, cell cycle transition, cytokinesis, morphogenesis, response to heat, and regulation of ascospore formation. It localizes to the cytoplasm, nucleus, cell tip, division septum, and cell division site. Phenotypic associations include increased replicative lifespan and oxidative stress resistance, increased heat sensitivity, decreased UV resistance and vegetative growth, as well as altered budding, cell cycle progression, and vacuolar morphology. The gene is also linked to turgor pressure, calcium sensitivity, oxidative stress, and light sensitivity. Studies of related genes in other species connect the family to loss of pathogenicity and reduced virulence.