DGA1 — Saccharomyces cerevisiae S288c

Summary

YOR245C (DGA1) on chromosome XV of Saccharomyces cerevisiae S288c encodes a diacylglycerol O-acyltransferase with 2-acylglycerol O-acyltransferase activity, placing it in the DAGAT family. The gene is associated with triglyceride anabolism, neutral lipid anabolism, lipogenesis, fatty acid anabolism, phospholipid metabolism, ceramide metabolism, glycosylation, and the Leloir pathway, as well as with triglyceride storage and mobilization, cellular triglyceride homeostasis, and lipid oxidation. DGA1 is linked to perinuclear and cortical ER, the ER membrane, the adiposome, and the cytoplasm. It has been connected to biomass yield, phosphate content, acid sensitivity, and oxidative stress, and to phenotypes including abnormal lipid particle morphology, decreased anaerobic growth, increased invasive growth, altered replicative and chronological lifespan, decreased starvation resistance, and altered chemical compound accumulation.