PHO85 — Saccharomyces cerevisiae S288c

Summary

YPL031C in Saccharomyces cerevisiae S288c encodes a cyclin-dependent protein kinase (CDK) with protein serine/threonine kinase activity, ATP binding, and cyclin binding capabilities. It is a component of the Pho85-Pho80 CDK-cyclin complex and localizes to the CDK holoenzyme, meiotic spindle, and spindle pole bodies. The gene is associated with the mitotic cell cycle, cell morphogenesis, response to stress, glycogen metabolism, chitin anabolism, GPI anchor anabolism, nucleocytoplasmic transport, actin polymerization, and the electron transport chain. It is linked to traits including phosphorus and potassium concentration, calcium sensitivity, and oxidative stress. Phenotypic associations include delayed cell cycle passage through START, decreased spore germination rate, absent fermentative growth, increased autophagy and mitophagy, decreased telomere length, abnormal actin cytoskeleton and cell morphology, decreased biofilm formation, and reduced replicative lifespan.