PMA2 — Saccharomyces cerevisiae S288c

Summary

YPL036W, also known as PMA1 or PMA2, encodes a P-type ATPase family protein on chromosome XVI of Saccharomyces cerevisiae S288c. The gene product exhibits proton-transporting ATPase activity, ATP binding, and metal binding, and is associated with proton binding, P-type potassium:proton transporter activity, and calcium ion binding. PMA1 is associated with regulation of pH, membrane polarization and depolarization, potassium ion export, sodium transport, water transport, and ATP metabolism. It has been associated with traits including potassium content and uptake, sugar content, manganese concentration, salt sensitivity, and oxidative stress. The protein localizes to the plasma membrane, ER membrane, Golgi membrane, and nuclear envelope. Studies of related genes in other species link the family to proton pump function and EC numbers 7.1.2.1 and 7.2.2.3.