GLR1 — Saccharomyces cerevisiae S288c

Summary

YPL091W, also known as GLR1, encodes a glutathione reductase in Saccharomyces cerevisiae S288c on chromosome XVI. This enzyme has glutathione reductase activity, dihydrolipoyl dehydrogenase (NADH) activity, and binds NADP and FAD or FADH2. GLR1 is associated with glutathione metabolism, response to oxidative stress, cellular oxidant detoxification, and responses to acetaldehyde, furfural, and menadione. It is linked to the glycine cleavage system, pyruvate dehydrogenase complex, and KGDHC, and localizes to mitochondria, peroxisomes, cytoplasm, and nucleus. The gene is associated with traits including respiration rate and oxidative stress, and phenotypes such as decreased replicative lifespan, increased cell size, altered redox state, and varied resistance to metals, chemicals, and hyperosmotic stress. Studies of related genes in other species link the family to EC 1.8.1.7 and EC 1.8.1.4 activities.