PEP4 — Saccharomyces cerevisiae S288c

Summary

YPL154C in Saccharomyces cerevisiae S288c encodes a vacuolar aspartic endopeptidase, belonging to the saccharopepsin and aspartic peptidase A1 families, with disordered domain specific binding and oligosaccharide binding activities. The gene is associated with numerous cellular processes including ribophagy, microautophagy, mitophagy, vacuolar transport, programmed cell death, apoptotic process, polyamine anabolism, catabolism, externalization of phosphatidylserine, cellular homeostasis, and regulation of sulfate assimilation. It is linked to traits such as biomass yield, phosphate content, protein content, and oxidative stress. Phenotypic associations include decreased ribophagy, absent mitophagy, abnormal autophagy, increased necrotic cell death, decreased viability, decreased stress resistance, decreased desiccation resistance, decreased chronological lifespan, decreased oxidative stress resistance, decreased innate thermotolerance, and abnormal vegetative growth. The gene localizes to the vacuolar lumen, fungal-type vacuole, macromolecular complex, and extracellular space.