GAL4 — Saccharomyces cerevisiae S288c

Summary

YPL248C encodes a DNA-binding transcription factor with RNA polymerase II-specific activity, containing a Zn2-C6 fungal-type DNA-binding domain and a Gal4 dimerization domain, and localizes to the nucleus. The gene is associated with the Leloir pathway and galactose metabolism, as well as with a wide range of biological processes including lateral inhibition, acute-phase response, chemosensory perception, and regulation of B cell proliferation. It has been linked to traits such as male sterility, potassium content, copper and iron concentrations, salt tolerance, and oxidative stress. Phenotypic associations include decreased utilization of carbon sources, reduced acid pH and UV resistance, increased invasive growth, altered competitive fitness, and increased heat sensitivity. Studies of related genes in other species link the family to stress response regulation.