VPS4 — Saccharomyces cerevisiae S288c

Summary

YPR173C in Saccharomyces cerevisiae S288c encodes a protein with GTPase inhibitor activity, microtubule-severing ATPase activity, membrane protein dislocase activity, protein transporter activity, ATP-dependent protein disaggregase activity, and polyubiquitin modification-dependent protein binding. It is associated with the ESCRT-IV, Vms1-Cdc48-Npl4, Hrd1p ubiquitin ligase, RQC, and p97-Ufd1-Npl4 complexes, and localizes to the external mitochondrial outer membrane. The gene is associated with numerous cellular processes including autophagy, mitophagy, ER-phagy, lipophagy, microlipophagy, endosomal transport, vacuolar fusion, pinocytosis, MVB formation, NPC assembly, protein secretion, cellular senescence, and response to nutrient levels. Phenotypic associations include decreased viability, sporulation, filamentous growth, invasive growth, replicative lifespan, and acid pH resistance, alongside increased calcium sensitivity, oxidative stress, and chemical compound excretion. Studies of related genes in other species link the family to loss of pathogenicity.