COX1 — Saccharomyces cerevisiae S288c

Summary

Q0045, also known as COX1, is a mitochondrial gene in Saccharomyces cerevisiae S288c that encodes a core subunit of cytochrome c oxidase (Complex IV), possessing cytochrome-c oxidase activity, heme binding, and metal binding functions. The protein localises to the mitochondrial inner membrane as part of the respiratory chain complex. COX1 is associated with cellular respiration, electron transport coupled proton transport, mitochondrial electron transport from cytochrome c to oxygen, oxidative phosphorylation, and light absorption. It has been linked to mitochondrial translation, transcription, tRNA modification, intron homing, group I intron splicing, protein lipoylation, heme A anabolism, karyogamy, and the retrograde response. The gene is connected to the petite phenotype, decreased hydrostatic pressure resistance, and absent or reduced respiratory growth. Related genes in other species link the family to cytochrome-c oxidase activity (EC 7.1.1.9).