PDR3 — Saccharomyces cerevisiae S288c

Summary

YBL005W in Saccharomyces cerevisiae S288c encodes a DNA-binding transcription activator with RNA polymerase II-specific activity, featuring a Zn2-C6 fungal-type DNA-binding domain and a Sec_Metabolite_Reg domain. The gene is associated with diverse biological processes including response to fungi and fungicide, TOR signaling, lipid homeostasis, alkane transport, UTP breakdown, methionine metabolism, detoxification, and cellular response to xenobiotic stimuli. It is linked to oxidative stress and salt tolerance traits. Phenotypic associations include decreased UV and metal resistance, altered chemical compound accumulation, changes in competitive fitness, and reduced vegetative growth rate. The protein localizes to the nucleus, cytosol, and fungal biofilm matrix. Related genes in other species are linked to increased virulence.