UGA2 — Saccharomyces cerevisiae S288c

Summary

YBR006W encodes a succinate-semialdehyde dehydrogenase (NAD+ and NADP+ activity) and also exhibits betaine-aldehyde dehydrogenase and broader aldehyde dehydrogenase activities. The protein belongs to the aldehyde dehydrogenase superfamily and is localised to the mitochondrial lumen, mitochondria, cytoplasm, cytosol, nucleus, Golgi complex, and extracellular space. YBR006W is associated with GABA metabolism and the GABA shunt, alanine and beta-alanine anabolism, choline oxidation, polyamine breakdown, acetaldehyde breakdown, and cellular detoxification of nitrogen compounds. It is also linked to bud expansion, snRNA modification, cell quiescence, posttranscriptional regulation of gene expression, carbon catabolite activation of transcription, vesicle transport, and innate immunity. Phenotypic associations include increased biofilm formation, increased chronological lifespan, altered competitive fitness, increased heat sensitivity, and altered resistance to chemicals and osmotic stress.