HSP26 — Saccharomyces cerevisiae S288c

Summary

YBR072W, also known as HSP26, encodes a small heat shock protein (HSP20-like chaperone) with protein folding chaperone, unfolded protein binding, and identical protein binding activities. In Saccharomyces cerevisiae, this gene is associated with diverse biological processes including protein folding and oligomerization, cellular responses to misfolded and unfolded proteins, developmental induction, oogenesis, cellular thermotolerance, and responses to freezing, salinity, and acetaldehyde. It is also linked to methylglyoxal anabolism, ethanal and glyoxylate metabolism, fatty acid breakdown, sulfur amino acid metabolism, protein oxidation, and pH reduction. The protein localizes to the cytoplasm, cytosol, nucleus, and protein aggregate centers. Phenotypic associations include altered fermentative metabolism rates, increased replicative lifespan, decreased starvation resistance and competitive fitness, and altered chemical resistance. Studies of related genes in other species link the HSP26 family to stress protection roles.