LYS2 — Saccharomyces cerevisiae S288c

Summary

YBR115C (LYS2) on chromosome II of Saccharomyces cerevisiae S288c encodes a protein with L-aminoadipate-semialdehyde dehydrogenase activity, ligase activity, phosphopantetheine binding, isomerase activity, and redox activity. The gene is associated with lysine biosynthesis via the aminoadipic acid pathway, amino acid activation for nonribosomal peptide biosynthesis, and the diaminopimelate pathway. It has been connected to peptide antibiotic and enterobactin anabolism, fermentation, cell death, wound healing, and DNA breakdown. Associations with traits include protein content, oxidative stress, and light sensitivity. Phenotypic links include abnormal nitrogen source utilization, auxotrophy, altered heat sensitivity, and altered chemical resistance. Studies of related genes in other species link the family to reduced virulence. The protein localizes to the cytoplasm and cytosol.