PCH2 — Saccharomyces cerevisiae S288c

Summary

YBR186W (PCH2) in Saccharomyces cerevisiae S288c on chromosome II encodes an ATP-dependent protein disaggregase with ATP hydrolase activity, polyubiquitin modification-dependent protein binding, and ATP binding. It belongs to the AAA+ ATPase and Pch2-like families. The gene is associated with meiosis I, Golgi reassembly, SNARE complex disassembly, DNA replication termination, mitochondrial protein quality control, spindle pole body separation, and membrane fusion. It is linked to lysosomal protein catabolism, CAT tailing, amylase release, metabolic burst, T cell activation, and activation of cellular response to hypoxic stress. Localization evidence connects the product to the Golgi stack, Vms1-Cdc48-Npl4 complex, Hrd1p ubiquitin ligase complex, RQC complex, p97-Ufd1-Npl4 complex, and external side of the mitochondrial outer membrane. Phenotypic associations include increased meiotic recombination, increased chronological lifespan, decreased chemical resistance, abnormal vacuolar morphology, and increased competitive fitness. Related genes in other species link the family to ATPase activity (EC 3.6.4.6 and 3.6.4.10).