LEU2 — Saccharomyces cerevisiae S288c

Summary

YCL018W, also known as LEU2, on chromosome III of Saccharomyces cerevisiae S288c, encodes a 3-isopropylmalate dehydrogenase (EC 1.1.1.85) that binds NAD and magnesium. The gene is associated with a wide range of biological processes, including L-leucine transport, regulation of amino acid transport, regulation of pH, DNA-mediated transformation, plasmid recombination, DNA integration, and the anabolism of cephalosporin C, 1-butanol, tetrahydrofolate, and phosphatidylserine. It is also linked to digestion, sexual flocculation, amyloid fibril formation, regulation of chromosome segregation, gpERAD, blood clotting, and fatty acid transport. The encoded protein localizes to the cytosol. Associations with traits such as sugar content, biomass yield, salt tolerance, and oxidative stress have been noted, along with phenotypes including auxotrophy, altered colony appearance, and changes in chemical compound accumulation and chemical resistance.