ABP1 — Saccharomyces cerevisiae S288c

Summary

YCR088W, also known as ABP1, encodes an actin-binding protein in Saccharomyces cerevisiae S288c on chromosome III. The protein contains an ADF-H domain and an SH3 domain, and it binds F-actin. ABP1 is associated with actin polymerization, F-actin severing, membrane invagination, vesicle formation, exocytosis, macropinocytosis, ruffle assembly, receptor internalization, signal transduction, cell migration, filamentous growth, morphogenesis, and donor selection. It localizes to the cortical actin cytoskeleton, actin patches, actin bodies, sites of polarized growth, cell tips, and cell division sites. The gene is linked to traits including potassium concentration and oxidative stress. Phenotypic associations include increased bipolar budding pattern, absent filamentous growth, abnormal actin cytoskeleton morphology, increased cell size, decreased sporulation efficiency, decreased endocytosis, increased invasive growth, increased replicative lifespan, and altered stress resistance.