GPD1 — Saccharomyces cerevisiae S288c

Summary

YDL022W (GPD1) on chromosome IV of Saccharomyces cerevisiae S288c encodes a protein with glycerophosphate dehydrogenase (NAD) activity, NAD binding, and protein homodimerization activity. The gene is associated with intracellular accumulation of glycerol, glycerol and sorbitol anabolism, gluconeogenesis, ethanol fermentation, and butanediol and acetoin anabolism. It is linked to peroxisome fission, protein refolding, and responses to heat, sorbitol, and curcumin. The product localizes to the cytosol, nucleus, and fungal biofilm matrix. Associations with traits include calcium and salt sensitivity, sugar content, turgor pressure, biomass yield, protein content, and oxidative stress. Phenotypic links include decreased hyperosmotic stress resistance, altered chronological lifespan, altered carbon source utilization, and altered vegetative growth rate. Studies of related GPD family members in other species link the family to glycerol-3-phosphate dehydrogenase (EC 1.1.1.8) activity.