ARP2 — Saccharomyces cerevisiae S288c

Summary

YDL029W in Saccharomyces cerevisiae S288c encodes a protein that is a structural constituent of the cytoskeleton, binds F-actin, and possesses ATP-binding and hydrolase activity. The gene is associated with actin nucleation, polymerization, crosslinking, and severing, as well as meiotic cytokinesis, spore wall assembly, and cytoplasmic streaming. It localizes to the Arp2/3 protein complex and the actomyosin contractile ring. Phenotypic associations include delayed cytokinesis, decreased endocytosis, abnormal actin cytoskeleton morphology, decreased sporulation efficiency, decreased spore germination, increased heat sensitivity, and decreased hyperosmotic stress resistance. The gene is also linked to abnormal bud morphology, decreased telomere length, and reduced competitive fitness. Studies of related genes in other species place the family within the broader actin/actin-like conserved sequence and ATPase nucleotide-binding domain families.