CDC48 — Saccharomyces cerevisiae S288c

Summary

YDL126C encodes Cdc48, an AAA-ATPase with ATP hydrolase and ATP-dependent protein disaggregase activity, and is a core component of the p97-Ufd1-Npl4, Vms1-Cdc48-Npl4, and Hrd1p ubiquitin ligase complexes. It is associated with protein transporter activity, polyubiquitin modification-dependent protein binding, and preribosome binding. The gene is linked to a wide range of cellular processes including Golgi reassembly, ribophagy, mitochondrial fusion, spindle breakdown, microtubule dynamics, sphingolipid metabolism, gluconeogenesis, the ERAD pathway, deubiquitination, chromatin organization, and cellular homeostasis. It localizes to the external side of the mitochondrial outer membrane, the mitotic spindle midzone, peroxisome membrane, and chromatin. Associations with traits include oxidative stress, and phenotypes linked to YDL126C include decreased ribophagy and autophagy, arrested cell cycle progression, abnormal spindle morphology, decreased telomere length, increased cold sensitivity, and absent respiratory growth. Related genes in other species link it to similar AAA-ATPase functions.